Chiral GC Applications

linalool / linalyl acetate on 6T-23Ac-beta-CD ("TA")

Simultaneous resolution of linalool and linalyl acetate

Simultaneous resolution of the enantiomers of linalool and linalyl acetate. This application is suited to separate and resolve the title compounds as commonly required in essential oil analysis.

A wide range of temperature programs may be used to optimise the method with regards to individual matrix requirements. Baseline separation can be achieved easily and quantitation is possible.

All columns of this type ("TA") supplied by Chiral-Separations.com are individually tested to achieve the resolution of both linalool and linalyl acetate.

Application-6T23Ac7-Linalool.pdf

Menthol and Menthone isomers on 6-Me-2,3-Pe-gamma-CD ("G")

Simultaneous resolution of several menthol and menthone isomers

All important isomers and enantiomers of menthone, isomenthone, neomenthol, neoisomenthol and menthol can be separated in a single run.

This is a demonstration of the outstanding separation capabilities regarding oxygenated monoterpenes and related classes as lactones, ethers and ketones.

Application-6Me23Pe8-Menthol.pdf

Ambrox on 6T-23Me-beta-CD ("TM")

Resolution of Ambrox

Enantiomeric resolution of ambrox with a high alpha value. Higher temperatures will give baseline separations in significantly shorter time.

Cyclodextrin TM is particularly suited for high temperature conditions, i.e. for low volatile analytes or rapid chromatography of medium volatile compounds.

Application-6T23Me7-Ambrox.pdf

sclareol, a diterpene, on 6T-23Me-beta-CD ("TM")

Resolution of sclareol

This application is an example for a diterpene resolution. Due to the high separation efficiency at elevated temperatures this stationary phase may be employed for the analysis of compounds with higher molecular weight and lower volatility.

Many polychlorinated biphenyls, halogenated pesticides, paracyclophanes and similar aromatic compounds may be separated and resolved.

This is the stationary phase of choice for low volatile analytes and high temperature conditions.

Application-6T23Me7-Sclareol.pdf

Spiroalkanes on 6-Me-2,3-Pe-gamma-CD ("G")

Resolution of spiroalkanes

Column "G" is particularly suited to separate medium-polar compounds like ethers, ketones,lactones, alkohols, esters and related substance classes like oxygenated monoterpenes and sesquiterpenes.

The majority of monoterpene hydrocarbons as well as many unsaturated or cyclic aliphates can be separated.

Even at fairly low temperatures (40 °C) excellent enantioseparations of high-volatile compounds can be achieved.

Application-6Me23Pe8-Spiroalkanes.pdf

4-methyl-3-heptanone on 6-Me-2,3-Pe-gamma-CD ("G")

Resolution 4-methyl-3-heptanone

A typical example of an excellent separation factor for a high-volatile, medium polar oxygenated compound.

Down to fairly low temperatures (40 °C) excellent enantioseparations of high-volatile compounds can be achieved. This is the stationary phase of choice for low temperature separations of highly volatile analytes.

Application-6Me23Pe8-Methylheptanone.pdf

Isotopic Isomers on 3-Bc-2,6-Pe-gamma-CD ("E")

Resolution of H/D-isotopomers

Column type "E" is particularly useful for all medium-polar compounds in the whole volatility range, from elution temperatures of 60 °C up to 180 °C.

This application shows the simultaneous enantioseparation of two isotopic isomers (hydrogen/deuterium) in all possible 4 species.

Cyclodextrin E is known for its wide variety of very special separation capabilities, mostly focusing on oxygenated functional group like alkcohols, esters, ethers, epoxides, lactones and related compounds.

Application-3Bc-26Pe8-Isotopomeres.pdf